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Cholinesterase
Cytotoxicity
FLICA
FLISP
FLIVO
Magic
Red, Caspase
Magic
Red, Cathepsin
Cholinesterase
reference
11 Huang, X., Lee, B. W., Johnson, G. L., Naleway, J.,
Guzikowski, A., Dai, W., Darzynkiewicz, Z. 2005. Novel
assay utilizing fluorochrome-tagged physostigmine (Ph-F) to in situ detect active
acetylcholinesterase (AchE) induced during apoptosis.
Cell Cycle 4:1, 140-147.
Cytotoxicity
reference
11 Olin, M. R., Choi, K. H., Lee, J., Molitor, T. 2005.
Gamma delta t-lymphocyte cytotoxic activity against
Mycobacterium bovis analyzed by flow cytometry. Journal
of Immunological Methods vol 297.
Poly-Caspases
FLICA
Green,
FAM-FLICA
1.
Amstad, P. A., G. Yu, G.L. Johnson, B.W. Lee, S. Dhawan and D.J. Phelps. 2001. Detection of caspase activation in situ by fluorochrome-labeled caspase inhibitors. Biotechniques vol 31:608-614.
2. Bedner, E., P. Smolewski, P. Amstad, and Z. Darzynkiewicz. 2000. Activation of caspases measured in situ by binding of fluorochrome-labeled inhibitors of caspases (FLICA): correlation with DNA fragmentation. Exp Cell Res vol 259:308-313
3. Buller, G., Bradford, J., Rothe, A., Janes, M., Salisbury, J., Ignatius, M., and Godfrey, W. 2004. Detection of apoptosis markers over time after induction. Poster presented at the American Society for Cell Biology, December, 2004.
4. Darzynkiewicz, Z., E. Bedner, P. Smolewski, B.W. Lee and G.L. Johnson. 2001. Detection of caspases activation in situ by fluorochrome-labeled inhibitors of caspase (FLICA). Meth. Mol. Biol. vol 203:289-299.
5. Darzynkiewicz, Z., J. Grabarek, H.D. Halicka, and P. Smolewski. 2002. Assay of caspase activation in situ combined with probing plasma membrane integrity to detect three distinct stages of apoptosis. Journal of Immunological Methods vol 265:111-121.
6. Gougeon, M. L., Lecoeur, H., 2002. Evaluation of apoptosis. Journal of Immunological Methods vol. 265, 1-2, 1 July 2002, pp. 1-2.
7. Grabarek, J., P. Amstad, and Z. Darzynkiewicz. 2002. Use of fluorescently labeled caspase inhibitors as affinity labels to detect activated caspases. Human Cell vol 15(1):1-12.
8. Grabarek, J., Darzynkiewicz, Z. 2002. In situ activation of caspases and serine proteases during apoptosis detected by affinity labeling their enzyme active centers with fluorochrome-tagged inhibitors. Exp. Hematology vol 30:982-989.
9. Graberek, J., Dragan, M., Lee, B. W., Johnson, G. L., Darzynkiewicz, Z. 2002. Activation of chymotrypsin-like serine protease(s) during apoptosis detected by affinity-labeling of the enzymatic center with fluoresceinated inhibitor. Int. J. Oncol vol 20:225-233.
10. Graberek, J., L. Du, G.L. Johnson, B.W. Lee, D.J. Phelps and Z. Darzynkiewicz. 2002. Sequential activation of Caspases and serine proteases (serpases) during apoptosis. Cell Cycle vol
1:124-131.
11. McQueen, T., S.M. Kornblau, M. Konopleva, K. Edwards, M. Andreeff, J. Cortes, E. Estey, and F. Giles. 2001. Caspase independent cell death in AML: An in vivo study in patients undergoing chemotherapy. Blood vol
98:208b.
12. Piguet, P. F., and C. Vesin. 2002. Modulation of platelet caspases and life-span by anti-platelet antibodies in mice. Eur J Haematol vol
68:253-61.
13. Pozarowski, P., X. Huang, D. H. Halicka, B. Lee, G. Johnson, and Z. Darzynkiewicz. 2003. Interactions of fluorochrome-labeled caspase inhibitors with apoptotic cells: a caution in data interpretation. Cytometry vol.
55A:50-60.
14. Smolewski, P., E. Bedner, L. Du, T.C. Hsieh, J.M. Wu, D.J. Phelps, and Z. Darzynkiewicz. 2001. Detection of caspases activation by fluorochrome-labeled inhibitors: Multiparameter analysis by laser scanning cytometry. Cytometry vol
44:73-82.
15. Smolewski, P., Grabarek, J., Halicka, H.D., and Darzynkiewicz, Z. 2002. Assay of caspase activation in situ combined with probing plasma membrane integrity to detect three distinct stages of apoptosis. Journal of Immunological Methods vol
265:111-121.
16. Smolewski, P., Grabarek, J., Lee, B. W., Johnson, G. L., Darzynkiewicz, Z. 2002. Kinetics of HL-60 cell entry to apoptosis during treatment with TNF-alpha or camptothecin assayed by the stathmo-apoptosis method. Cytometry vol.
47:143-149.
17. Teodori, L., Grabarek, J., Smolewski, P., Ghibelli, L., Bergamaschi, A., De Nicola, M., and Darzynkiewicz, Z. 2002. Exposure of cells to static magnetic field accelerates loss of integrity of plasma membrane during apoptosis. Cytometry vol
49(3):113-118.
18. Valero, A., Merino, F., Wolbers, F., Luttge, R. Vermes, I., Andersson, H. and van den Berg, A. 2005. Apoptotic cell death dynamics of HL60 cells studied using a microfluidic cell trap device. Lab Chip vol
5:49-55.
19. Widen, R., C.A. Newton, T.W. Klein, and H. Friedman. 2001. Apoptosis of thioglycollate-elicited macrophages from A/J mice infected with virulent Legionella pneumophila. Abstracts of the General Meeting of the American Society for Microbiology vol
101:295-296.
20. Wlodkowic, D., Skommer, J., Pelkonen, J. 2006. Multiparametric analysis of HA14-1-induced apoptosis in follicular lymphoma cells. Leuk Res vol
30(9):1187-1192.
21. Wolbers, F., Buijtenhuijs, P., Haanen, C., and Vermes, I. 2004. Apoptotic cell death kinetics in vitro depend on the cell types and the inducers used. Apoptosis vol 9:385-392.
Poly-Caspases
FLICA
Red,
SR-FLICA
1. Fiala, M., Lin, J., Ringman, J., Kermani-Arab, V., Tsao, G., Patel, A., Lossinsky, A.S., Graves, M.C. Gustavson, A., Sayre, J., Sofroni, E., Surarez, T., Chiappelli, F. and Bernard, G. 2005. Ineffective phagocytosis of amyloid-â by macrophages of Alzheimer’s disease patients. Journal of Alzheimer’s Disease vol 7:221-232.
2. Graberek, J., L. Du, G.L. Johnson, B.W. Lee, D.J. Phelps and Z. Darzynkiewicz. 2002. Sequential activation of Caspases and serine proteases (serpases) during apoptosis. Cell Cycle vol 1:124-131.
3. Osborne, M. K., Maxey, J. A., Bell, Wade E. 2004. Caspase inhibitors block entry into autogamy in Paramecium tetraurelia. Poster presented at the American Society for Microbiology, 2004.
4. Tinner-Staines, B., VandenHoek, S. 2004. Using cryopreserved neuronal cells for multiwell neurotoxicity assays. Poster presented at the Society for Neuroscience October 2004 annual meeting.
Caspase
1 FLICA,
Green
1. Grabarek, J., P. Amstad, and Z. Darzynkiewicz. 2002. Use of fluorescently labeled caspase inhibitors as affinity labels to detect activated caspases. Human Cell vol 15(1):1-12.
2. Grabarek, J., and Z. Darzynkiewicz. 2002. In situ activation of caspases and serine proteases during apoptosis detected by affinity labeling their enzyme active centers with fluorochrome-tagged inhibitors. Exp. Hematology vol 30:982-989.
3. Grunewald, S., Paasch, U., Said, T.M., Sharma, R.K., Glander, H.J., Agarwal, A. 2005. Caspase activity in human spermatozoa in response to physiological and pathological stimuli. Fertility and Sterility vol 83:1106-1112.
4. Scotton, C.J., Martinez, F.O., Smelt, M.J., Sironi, M., Locati, M., Mantovani, A., and Sozzani, S. 2005. Transctiptional profiling reveals complex regulation of the monocyte IL-1â system by IL-13. The Journal of Immunology. 834-845.
Caspase
2 FLICA,
Green
1. Grabarek, J., P. Amstad, and Z. Darzynkiewicz. 2002. Use of fluorescently labeled caspase inhibitors as affinity labels to detect activated caspases. Human Cell vol 15(1):1-12.
2. Grabarek, J., and Z. Darzynkiewicz. 2002. In situ activation of caspases and serine proteases during apoptosis detected by affinity labeling their enzyme active centers with fluorochrome-tagged inhibitors. Exp. Hematology vol 30:982-989.
Caspase
3&7 FLICA,
Green
and Red
1. Bianco, F., Pravettoni, E., Colombo, A., Schenk, U., Moller, T., Matteoli, M., and Verderio, C. 2005. Astrocyte-derived ATP induces vesicle shedding and IL-1â release from microglia. The Journal of Immunology vol 174:7268-7277.
2. Chwa, M., Atilano, S. R., Reddy, V., Jordan, N., Kim, D. W., Kenney, M. C. 2006. Increased stress-induced generation of reactive oxygen species and apoptosis in human keratoconus fibroblasts. Investigative Ophthalmology and Visual Science May 2006 vol 47, no. 5, 1902-1910.
3. Feng, Y., Hu, J., Xie, D., Oin, J., Zhong, Y., Li, X., Xiao, W., Wu, J., Tao, D., Zhang, M., Zhu, Y., Song, Y., Reed, E., Li, O.O., and Gong, J. 2005. Subcellular localization of caspase-3 activation correlates with changes in apoptotic morphology in MOLT-4 leukemia cells exposed to X-ray irradiation. Int J Oncol vol 27(3):699-704.
4. Feng, Y.D., Xie, D.X., Oin, J.C., Zhong, Y.S., Li, X.L., Xiao, W., Wu, J.H., Tao, D.D., Hu, J.B., and Gong, J.P. 2004. Correlation of intra-cellular localization and variations of active caspase-3 to morphology changes in apoptotic MOLT-4 cells induced by X-ray. Ai Zheng vol 23(9):1011-1015.
5. Fiala, M., Papik, W., Qiao, J.H., Lossinsky, A.S., Alce, ,T. Tran, K., Yang, W. Roos, K.P., Arthos, J. 2004. HIV-4 induces cardiomyopathy by cardiomyocyte invasion and gp120, Tat and cytokine apoptotic signaling. Cardiovasc Toxicol vol 4(2):97-107.
6. Grabarek, J., P. Amstad, and Z. Darzynkiewicz. 2002. Use of fluorescently labeled caspase inhibitors as affinity labels to detect activated caspases. Human Cell vol 15(1):1-12.
7. Grabarek, J., and Z. Darzynkiewicz. 2002. In situ activation of caspases and serine proteases during apoptosis detected by affinity labeling their enzyme active centers with fluorochrome-tagged inhibitors. Exp. Hematology vol 30:982-989.
8. Grunewald, S., Paasch, U., Said, T.M., Sharma, R.K., Glander, H.J., Agarwal, A. 2005. Caspase activity in human spermatozoa in response to physiological and pathological stimuli. Fertility and Sterility vol 83:1106-1112.
9. Kahraman, S., Zup, S. L., McCarthy, M. M., Fiskum, G. October 18, 2006. GABAergic mechanism of propofol toxicity in immature neurons. Poster presented at the 2006 Society for Neuroscience annual meeting.
10. Kon, K., Kim, J. S., Jaeschke, H., Lemasters, J. J. 2004. Mitochondrial permeability transition in acetaminophen-induced necrosis and apopotsis of cultured mouse hepatocytes. Hepatology 40:1170-1179.
11. Paasch, U., Sharma, R.K., Gupta, A.K., Grunewald, S., Mascha, E.J., Thomas, A.J. Jr., Glander, H.J., and Agarwal, A. 2004. Cryoperservation and thawing is associated with varying extent of activation of apoptotic machinery in subsets of ejaculated human spermatozoa. Biology of Reproduction vol 71:1828-1837.
12. Takahashi, A., Hanson, M.G.V., Norell, H. R., Havelka, A. M., Kono, K., Malmberg, K.J., and Kiessling, R.V.R. 2005. Preferential cell death of CD8+ effector memory (CCR7-CD45RA-) T cells by hydrogen peroxide-induced oxidative stress. The Journal of Immunology. 6080-6087.
13. Trummell, H.Q., Raisch, K.P., Seay, L.L., and Bonner, James, A. 2004. AKT activity following exposure to IMC-C225 alone, radiation alone or a combination of both treatments. Poster presented at the American Association for Cancer Research, March 27-31, 2004, abstract # 1293.
14. VanOsten, R.L., Moore, J.M., Karacay, B. Griffith, T.S. 2005. Histone deacetylase inhibitors modulate renal cell carcinoma sensitivity to TRAIL/Apo-2L-induced apoptosis by enhancing TRAIL-R2 expression. Cancer Biology & Therapy vol 4, issue 10:31-39.
Caspase
6 FLICA,
Green
1. Bedner, E., P. Smolewski, P. Amstad, and Z. Darzynkiewicz. 2000. Activation of caspases measured in situ by binding of fluorochrome-labeled inhibitors of caspases (FLICA): correlation with DNA fragmentation. Exp Cell Res vol 259:308-313
2. Grabarek, J., P. Amstad, and Z. Darzynkiewicz. 2002. Use of fluorescently labeled caspase inhibitors as affinity labels to detect activated caspases. Human Cell vol 15(1):1-12.
3. Grabarek, J., and Z. Darzynkiewicz. 2002. In situ activation of caspases and serine proteases during apoptosis detected by affinity labeling their enzyme active centers with fluorochrome-tagged inhibitors. Exp. Hematology vol 30:982-989.
Caspase
8 FLICA,
Green
1. Grabarek, J., P. Amstad, and Z. Darzynkiewicz. 2002. Use of fluorescently labeled caspase inhibitors as affinity labels to detect activated caspases. Human Cell vol 15(1):1-12.
2. Grabarek, J., and Z. Darzynkiewicz. 2002. In situ activation of caspases and serine proteases during apoptosis detected by affinity labeling their enzyme active centers with fluorochrome-tagged inhibitors. Exp. Hematology vol 30:982-989.
3. Grunewald, S., Paasch, U., Said, T.M., Sharma, R.K., Glander, H.J., Agarwal, A. 2005. Caspase activity in human spermatozoa in response to physiological and pathological stimuli. Fertility and Sterility vol 83:1106-1112.
4. Kemp, T.J., Ludwig, A.T., Earel, J.K., Moore, J.M., VanOosten, R.L., Moses, B., Leidal, K., Nauseef, W.M. and Griffith, T.S. 2005. Neutrophil stimulation with Mycobacterium bovis bacillus Calmette-Guerin (BCG) results in the release of functional soluble TRAIL/Apo-2L. Blood vol 106(10):3474-3482
5. Paasch, U., Sharma, R.K., Gupta, A.K., Grunewald, S., Mascha, E.J., Thomas, A.J. Jr., Glander, H.J., and Agarwal, A. 2004. Cryoperservation and thawing is associated with varying extent of activation of apoptotic machinery in subsets of ejaculated human spermatozoa. Biology of Reproduction vol 71:1828-1837.
6. Tatari-Calderone, Z., Brogdon, J.L., Tinsley, K.W., Ramezani, A., and Leitenberg, D. 2005. CD4-dependent signaling is required for a late checkpoint during Th2 development associated with resistance to activation-induced cell death. The Journal of Immunology vol 175:5629-5636
7. VanOsten, R.L., Moore, J.M., Karacay, B. Griffith, T.S. 2005. Histone deacetylase inhibitors modulate renal cell carcinoma sensitivity to TRAIL/Apo-2L-induced apoptosis by enhancing TRAIL-R2 expression. Cancer Biology & Therapy vol 4, issue 10:31-39.
8. Wang, Z., Goulet, R. 3rd, Stanton, K.J., Sadaria, M., and Nakshatri, H. 2005. Differential effect of anti-apoptotic genes Bcl-xL and c-FLIP on sensitivity of MCF-7 breast cancer cells to paclitaxel and docetaxel. Anticancer Res vol 25(3c):2367-2379.
Caspase
9 FLICA,
Green
1. Grabarek, J., P. Amstad, and Z. Darzynkiewicz. 2002. Use of fluorescently labeled caspase inhibitors as affinity labels to detect activated caspases. Human Cell vol 15(1):1-12.
2. Grabarek, J., and Z. Darzynkiewicz. 2002. In situ activation of caspases and serine proteases during apoptosis detected by affinity labeling their enzyme active centers with fluorochrome-tagged inhibitors. Exp. Hematology vol 30:982-989.
3. Grunewald, S., Paasch, U., Said, T.M., Sharma, R.K., Glander, H.J., Agarwal, A. 2005. Caspase activity in human spermatozoa in response to physiological and pathological stimuli. Fertility and Sterility vol 83:1106-1112.
4. Paasch, U., Sharma, R.K., Gupta, A.K., Grunewald, S., Mascha, E.J., Thomas, A.J. Jr., Glander, H.J., and Agarwal, A. 2004. Cryoperservation and thawing is associated with varying extent of activation of apoptotic machinery in subsets of ejaculated human spermatozoa. Biology of Reproduction vol 71:1828-1837.
5. inner-Staines, B., VandenHoek, S. 2004. Using cryopreserved neuronal cells for multiwell neurotoxicity assays. Poster presented at the Society for Neuroscience October 2004 annual meeting.
6. Trummell, H.Q., Raisch, K.P., Seay, L.L., and Bonner, James, A. 2004. AKT activity following exposure to IMC-C225 alone, radiation alone or a combination of both treatments. Poster presented at the American Association for Cancer Research, March 27-31, 2004, abstract # 1293.
7. VanOsten, R.L., Moore, J.M., Karacay, B. Griffith, T.S. 2005. Histone deacetylase inhibitors modulate renal cell carcinoma sensitivity to TRAIL/Apo-2L-induced apoptosis by enhancing TRAIL-R2 expression. Cancer Biology & Therapy vol 4, issue 10:31-39.1.
8. Wang, Z., Goulet, R. 3rd, Stanton, K.J., Sadaria, M., and Nakshatri, H. 2005. Differential effect of anti-apoptotic genes Bcl-xL and c-FLIP on sensitivity of MCF-7 breast cancer cells to paclitaxel and docetaxel. Anticancer Res vol 25(3c):2367-2379.
Caspase
10 FLICA,
Green
1. Grabarek, J., P. Amstad, and Z. Darzynkiewicz. 2002. Use of fluorescently labeled caspase inhibitors as affinity labels to detect activated caspases. Human Cell vol 15(1):1-12.
2. Grabarek, J., and Z. Darzynkiewicz. 2002. In situ activation of caspases and serine proteases during apoptosis detected by affinity labeling their enzyme active centers with fluorochrome-tagged inhibitors. Exp. Hematology vol 30:982-989.
Serine
Protease FLISP
1. Grabarek, J., and Darzynkiewicz, Z. 2002. In situ activation of caspases and serine proteases during apoptosis detected by affinity labeling their enzyme active centers with fluorochrome-tagged inhibitors. Exp. Hematology vol 30:982-989.
2. Graberek, J., L. Du, G.L. Johnson, B.W. Lee, D.J. Phelps and Z. Darzynkiewicz. 2002. Sequential activation of Caspases and serine proteases (serpases) during apoptosis. Cell Cycle vol 1:124-131.
3. O’Connell, A.R., Holohan, C., Torriglia, A., Lee, B.F., and Stenson-Cox, C. 2006. Characterization of a serine protease-mediated cell death program activate in human leukemia cells. Experimental Cell Research vol 312: 27-39.
4. O’Connell, A.R., Lee, B.W., and Stenson-Cox, C. 2006. Capase-dependant activation of chymotrypsin-like proteases mediates nuclear events during Jurkat T cell apoptosis. Biochem Biophys Res Commun vol 345(2):608-616.
In
Vivo Apoptosis FLIVO
1. Griffin, R.J., Williams, B.W., Loren, M., Bischof, J.C., Olin, M., Lee, B.W., and Johnson, G. 2006. Novel use of highly specific poly-caspase inhibitor for in vivo detection of apoptosis in tumors treated with vascular targeting agents. Poster presented at the American Association for Cancer Research, April 2006.
2. Griffin, R., Williams, B.W., Olin, M., Lowen, M., and Song, C.W. 2005. Thermoradiotherapy enhancement with anti-vascular strategy. Poster presented at the Radiation Research Society, October 17, 2005.
3. Morrow, T., Paulson, E. October 16, 2006. Diabetes-induced allodynia: correlation between behavioral intensity, duration of diabetes, and periaqueductal gray (PAG) activation. Poster presented at the Society for Neuroscience annual meeting, October 2006.
4. Olin, M., Roy, S., Peterson, P., and Moliter, T. 2006. In vivo model for the detection of morphine-induced apoptosis. Poster presented at the Society of Neuroimmunology Pharmacology (SNIP), April, 2006.
Magic
Red, Caspases 3&7
1. Lee, B. W., Johnson, G. L., Hed, S. A., Darzynkiewicz, Z., Talhouk, J., Mehrotra, S. 2003. DEVDase detection in intact apoptotic cells using the cell permeant fluorogenic substrate, (z-DEVD)2-cresyl violet. BioTechniques vol. 35, no. 5: 1080-1085.
Magic
Red, Cathepsins B, K, or L
1. Creasy, B., Hartmann, C., Higgins White, F., and McCoy, K. 2006. New assay using fluorogenic substrates and immunofluorescence staining to measure cysteine cathepsin activity in live cell subpopulations. Not yet published.
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